International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal. Lizi Jiaohuan Yu Xifu/Ion Exchange and Adsorption Fa yi xue za zhi Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology Research Journal of Chemistry and Environment

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-29-03-2023-1603
Total View : 483

Abstract : Diabetes is the most common medical complication of pregnancy. Vitamin D deficiency which was initially considered only to influence bone metabolism, is now known to exert a wide spectrum of extra-skeletal effects. Vitamin D deficiency is closely associated with gestational diabetes mellitus, it also leads to adverse maternal and child outcome. Only few Indian studies are available in this regard. The present study was undertaken to find association of Serum Vitamin D status with gestational diabetes mellitus and other laboratory parameters. A single centred, institution based, prospective birth cohort study was carried out from January 2022 to December 2022 at the department of biochemistry, Jalpaiguri Government Medical College, West Bengal, India after obtaining ethical clearance. 150 patients with GDM and 150 patients with normal blood sugar were involved in this study. The data was tabulated in Microsoft Excel software and analysed with SPSS V.24 software. Mean age of patients with GDM was 23.45±5.361and mean age without GDM was 23.19±5.51. Mean BMI was higher in case (28.16±4.6) group compared to that in control group (24.63±4.1). Mean FBS was higher in case (117.85±6.7) group compared to that in control group (85.55±0.5), mean PPBS was also higher in case (175±1.4) group compared to that in control group (103.11±0.6). The mean serum vitamin D level was lower in case group case (17.43±0.8) compared to that in control group (27.14±1.07). Women with vitamin D deficiency have an increased risk of developing GDM and other complications as compared to those who had normal level of vitamin D..
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International Medical Journal
Journal ID : IMJ-16-03-2023-1601
Total View : 438

Abstract : It was suggested that the risk of prostate cancer is associated with vitamin D deficiency. In this case, one has investigated the hypothesis that the 25 (OH) D statuses affect prostate specific antigen levels. In this regard we studied the association of vitamin D blood status with serum prostate specific antigen (PSA) concentrations. A total of 491 healthy men were diagnosed through the project. We have enlisted 491 Moroccan men of good health. The vitamin D status and serum PSA have been evaluated. The deficiency of Vitamin D (less than 30 ng /ml) was found in 81.7% of the study population. The mean vitamin D level in this population was 22.5 ±9.56 ng /ml. Serum vitamin D and PSA levels, respectively, were significantly negatively associated with age (p < 0.001, 0.005), while no correlation was found linking PSA and vitamin D levels. Our results show that even in regions like ours where there is a lot of sunlight all year round, vitamin D deficiency is widespread. Nevertheless, variations in vitamin D have shown no impact on healthy men's serum PSA levels..
Full article
International Medical Journal
Journal ID : IMJ-01-03-2023-1600
Total View : 486

Abstract : The endoribonuclease L (RNASEL) is the effector of the 2–5A system, a major enzymatic pathway regulated by interferons, encodes a ribonuclease that plays a significant role in the apoptotic pathway. RNASEL gene has been traditionally associated with Hereditary Prostate Cancer 1 and disease severity. Hereditary genetic alterations in RNASEL affect apoptotic responses, such mutations could possibly contribute to malignancy. In order to investigate the genetic alterations of the RNASEL gene in prostate cancer patients and correlation with clinical and pathological parameters, DNA samples from 100 blood samples from prostate cancer patients were genotyped and confirmed by Sanger sequencing. The frequency and distribution of high frequent mutations were determined and correlated with the patient’s tumor characteristics. Among 100 patients 74 % were carriers to one or more mutations in RNASEL gene. Our results revealed the detection of the RNASEL germline mutations, Arg462Gln variant, a common missense variant causing threefold reduction in enzymatic activity, with a high frequency (58%) in the Moroccan men with prostate cancer. In addition, One of the 100 patients have a nonsense substitution with 1% frequency and for synonymous mutations two substitutions have been detected, c.1263T>C and c.1416T>C with 3% and with 2% frequency rate respectively and frameshift mutations frequency were c.1250_1251insT in 7 patients, c.1256delC in 4% of patients while c.1257delA, c.1351delG and c.1395delG 3 have the same frequency 3%. Five of the most eight frequent missenses detected in our study were predicted to alter the RNASEL protein in all three powerful servers (SIFT, PolyPhen2 and PredictSNP), Those missense variants probably reduce the function of RNASEL as kinase enzyme leading to a defect in protein pathway as tumor suppressor genes. Interestingly, those missense variants were located in the RNASEL protein kinase-like domain. No significant differences between carriers and non-carriers of common mutations detected regarding Pathological Gleason score, PSA concentration, Tumor stage and age at diagnosis, [p > 0.05]. family history data and Clinical significance of mutations detected on prostate tumors progression can be investigated in future analysis. Our findings revealed novel RNASEL alterations in prostate cancer patients and it could be associated with cancer development..
Full article
International Medical Journal
Journal ID : IMJ-25-02-2023-1599
Total View : 441

Abstract : Most studies on the role of oncogenic viruses in the development of prostate carcinoma focus on one particular type of virus without analysing the different interactions that may exist between two or more types of virus. The objective of this study was to examine co-infection with BKPyV, MCPyV, PyV6 and PyV7 viruses in men with PCa (Pca) and their correlations with characteristics clinicopathologic patients. In this study, a total of 80 samples were summer analyzed ; 50 blood samples from of men patients with PCa have summer used to detect BKPyV, MCPyV, PyV6 and PyV7 in blood samples using PCR techniques and 30 control samples, and clinical significance has been analyzed statistically. Of the 50 samples tested, 36% were infected with BKPyV, 24% with PyV6 and 28% with PyV7. A correlation significant to summer observed between the Pathological Gleason score and BMI in co- infected patients. In fact, she can to have an important role in initiation and/ or growth of oncogenic transformation. Our results show that BKPyV PyV6 and PyV7 are cofactors potential for PCa in cases positive for BKPyV, which may lead to the development of new therapies and vaccines preventive..
Full article
International Medical Journal
Journal ID : IMJ-23-02-2023-1598
Total View : 490

Abstract : Cervical cancer (CC) is considered the fourth most common malignancy and the fifth fatal cancer in women, oncogenic Human papillomavirus (HPV) are considered a primary cause of development of cervical cancer. It has also been suggested that viral coexistence may also accelerate the progression of cervical lesions to cervical cancer. This study aims to study the coinfection of Epstein Bar Virus (EBV), Herpesvirus 8 (HHV8) and Hepes simplex type 2 (HSV2) infections in women with cervical cancer with the presence of HPV and their correlations with the clinicopathologic characteristics of patients. In this study, 73 samples that tested positive for Human papillomavirus in previous study were used for the detection of EBV, HHV8 and HSV2 in tumor tissue using Polymerase Chain Reaction techniques, and the clinical relevance was analyzed statistically. The 73 samples (48%) were infected with EBV, (24.65%) infected with HHV8 However, none of the cases were infected with HSV2. The frequency of co-infections was 22% of cases. No significant association was found between co-infection and other clinicopathologic features. Therefore, these results represent arguments in favor of the role of EBV and HHV8 among HPV positive cases, as potential cofactors in cervical carcinogenesis, which could lead us to develop new therapeutics and preventive vaccines..
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