: To study the effect of entropy monitoring on isoflurane consumption in patients undergoing general anaesthesia. A total of 30 patients each (total n=60 patients) were included in two groups: Group E (study group) and Group C (comparator/control group). Minimum MAC of 0.6 was maintained, the amount of isoflurane required was titrated according to the allocated group of patient. All monitoring data were recorded manually on proforma at baseline, at 5, 10, 20 and 30 minutes, 1, 1.5 & 2 hours’ interval beginning from the start of controlled ventilation after induction. The MAC values and Entropy score were non-significant at baseline (p value > 0.05), but were significantly higher in Group C at all the other time points (p value < 0.05) as compared to group E, statistically significant. In addition, Group E displayed early time to open eyes, early time to extubation and time to shift to recovery and lesser consumption of Isoflurane, with no serious adverse events. Entropy group showed better ENTROPY scores and MAC values. Group E can be employed as an adjunctive anaesthetic measure in patients requiring general anaesthesia & will also help to facilitate volatile anaesthetic titration, reduced consumption..