Vol - 28, Issue - 04
About the Journal
[This article belongs to Volume - 28, Issue - 04]
International Medical Journal
Journal ID : IMJ-22-03-2021-803
Total View : 374

Abstract : Vitamin D levels have been proven to influence many malignancies such as Colonic and Prostate cancer. Although observational studies have shown similar protective effect in influence, prospective and Randomised Control Trials do not support the same. This has caused confusion. The aim of this study was to correlate low levels of vitamin D3 as a risk factor for CA breast and to study the relationship between vitamin D levels and Disease free survival, Progress of the disease and Recurrence of disease. We conducted a Prospective (Nested) Case Control study on patients above 30 years of age, attending the Out Patient Department of General Surgery in Dr. D.Y. Patil Medical College, Pimpri, Pune. The study has two parts Baseline Vitamin D levels are assessed and tabulated between breast cancer patients and patients without breast cancer. The breast cancer patients (Nested) were divided into two groups, Group A: Received Vitamin D was supplementation and Group B: No Vitamin D supplementation was given. These two groups were prospectively followed up for 18 months to see relationship with Disease free survival, Recurrence and Progress of the disease. Vitamin D levels were significantly lower in Breast Cancer patients compared to normal ones, in both premenopausal and postmenopausal women. Vitamin D supplementation did not significantly improve Disease Free survival, Recurrence and Disease Progression. This study has found that there is a significant inverse association between Vitamin D levels and breast cancer risk. Women with Vitamin D levels lesser than 20 ng/ml have higher risk of breast cancer. Low Vitamin D levels is a significant risk factor of breast cancer, independent of menopausal status and Hormone receptor status. We also found, in the 18 months of follow up, Vitamin D supplementation has a weakly positive influence disease free survival, recurrence and progress of the disease. A larger study with a similar design and longer follow up will provide stronger evidence so that standardized protocols can be drawn regarding Vitamin D levels in breast cancer.

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