: Within the period of 2009-2015 there were 4241 cases of mortality from coronary heart disease (CHD) in Nur-Sultan city with a gradual decline from 840 cases in 2009 to 510 cases in 2015. As patient age increases, there is a higher mortality rate, which achieves the highest values in age stratum of >75 years. Out of those individuals who are younger than 75 years, the majority were males, while in the senile age group (>75 years), there were two times more females than males. Both women and men had increased mortality rates during the warm season (April-October). There was a significant relationship between average daily air temperature (tav) with lags of 1 and 3 days. With a decrease in ambient air temperature equal to 1°C, the mortality rate increased from 0.993 to 0.994 times, while with the increase in air temperature, the mortality declined, correspondingly. Mortality from CHD decreased together with the increase in effective (ET) and equivalently effective (EET) temperature by 1 °C by 2.17 % and 1.52 %, respectively with the exception of people aged 45-59 years. In patients with CHD aged 18-44 years, an increase in ET by 1ºC was accompanied by the decrease in mortality equal to 0.33 %. An increase in EET by 1°C among the elderly and senile patients reduced the mortality from CHD by 0.45% and 0.48%, respectively. In general, an increase in the average relative air humidity by 1 % leads to the decrease in mortality from CHD by 0.21 %.