: Early healing of periodontal wounds in oral cavity may be critical to the treatment outcome. This study examined the effects of oral pomegranate peel extract on the healing of surgically induced full thickness of the gingival wound in terms of histopathological aspect. A total of 30 healthy adult New Zealand female rabbits were randomly divided into two equal classes of incised wounds groups, experimental and control. The experimental group as study daily orally received 1 ml of Punica Granatum L., beginning on the first day of surgical gingival wound, continue 10 days after surgery, using a wound healing pattern. While; the animals in the control group, their surgical gingival wound pattern has been left untreated. In histological findings, scarification was undertaken for the healing periods (1, 8 and 15 days) of animals bearing a given gingival wound. The result of this study showed that the oral applications of Pomegranate peel extract promoted the process of wound healing particularly epithelial regeneration and collagen density with highly vascularized connective tissue remarkably in comparison with control group. In addition, the histological finding of our material revealed that, in general terms, it had all the hallmarks of complete healing. To conclude, results showed that oral administrations Pomegranate peel extract can stimulate healing properties on gingival wounds, in rabbit's model.