: Cardiovascular disease causes a number one world compared to other diseases. Cardiovascular disease can be predicted with several measuring instruments, one of which is the Framingham Risk Score (FRS). FRS is used to calculate the estimated risk of cardiovascular disease in the next ten years. This study was conducted to determine the relationship of age, sex, treatment of hpertension, history of diabetes mellitus, smoking behaviour, blood pressure, and BMI with the risk of cardiovascular disease. This type of research is a descriptive-analytic with approach cross-sectional. The population is employees at Respati University, Yogyakarta. The sampling technique uses incidental sampling, that is 79 respondents. The instruments used were the Framingham Risk Score, digital Sphygmanometer, Microtoise, and digital scales. Bivariate test using Somers'D. Most of the respondents in late adulthood were 32 respondents (40.5%), the sex of the male battery was 56 respondents (70.9%), did not take hypertension treatment that is 60 respondents (75.9%), did not have diabetes mellitus 73 respondents (92.4%), and nonsmokers, 58 respondents (73.4%). Bivariate test results between age, sex, history of diabetes mellitus, smoking behaviour, blood pressure, BMI, and treatment of hypertension with a risk of cardiovascular disease were p-values 0.002; 0,000; 0.003; 0.005; 0.005; 0.007; and 0, 089. There is a relationship between age, sex, history of diabetes mellitus, active smokers, blood pressure, and BMI with the risk of cardiovascular disease while hypertension treatment is not related to the risk of cardiovascular disease.