: Stroke is a public health problem in Romania, with important medical, social, and financial implications, sustained efforts being made to improve post-stroke rehabilitation phase. A significant concern nowadays is the patient's quality of life (QoL); a successful stroke recovery therapy implies the increasing of QoL index. However, there are very few studies evaluating patients’ QoL after stroke in Romania. In this context, the aim of this study is to evaluate the benefits that one-year rehabilitation therapy brings to a patient with a history of ischemic stroke, highlighting the factors that influence the QoL index. A prospective study was conducted in which the QoL (calculated using the stroke-specific QoL questionnaire) was measured in a group of 40 patients who had suffered an ischemic stroke in the left middle cerebral artery territory and benefited from rehabilitation therapy for one year. Patients admitted in our Neurology Department between January 2018–June 2019 were divided into several subgroups according to age, gender, domicile, educational level, familial support, and comorbidities. Statistical data were processed in SPSS v.20. Young age (under 60), urban domicile, high educational level, and family support are positive factors for QoL improvement after one year of stroke rehabilitation, while patient’s gender does not influence the outcome of the therapy. Stroke rehabilitation treatment is an essential component for improving the QoL of the patient after stroke; it has become topic of concern in the literature nowadays. This work complements the existing data on this topic for stroke patients in Romania.