: In Morocco, cancer is the second leading cause of death with (13.4%) behind circulatory diseases and heart disease. This rate can be reduced by preventive measures, good diagnosis and effective treatment, and by a very good knowledge of the phenomenon. A retrospective descriptive and analytical study of in-hospital mortality at the Marrakech Oncology Center was conducted by exploiting the records of cancer decedents between January 2014 and December 2018. The collection involved socio-demographic, economic and geographic variables. The evaluation of cancer mortality was estimated by calculating crude mortality rates, case fatality rates, main fatal cancers, as well as studying the survival of hospitalized cancer patients. The data were analyzed on SPSS version 24. It was based on descriptive and analytical statistics The survival study was considered using the Kaplan and Meir survival study. Crude cancer mortality rate estimated at 1.29 per 100,000 populations, men accounted for 53% (p<0.0001). The mean age was 52.86 years SD, 14.97 (p<0.0001), the majority of deaths were married (83%) (P=0.000), urban (74%), majority from the city of Marrakech 61% (p<0.0001), without professions (65%) and they were poor and vulnerable (90%). Women died of breast cancer (39%), colorectal cancer (12%), cervical cancer and stomach cancer (6%) respectively. Men died from lung (25%), stomach (9%), colorectal (8%) and bronchial (6%) cancer. The case fatality rate for cancer patients at the hospital level was 1.56%. For the four main causes of death for all sexes, 50% of colorectal cancer patients survived less than 9 months. 50 % of stomach cancer patients survived less than three months. Also 50% of breast and lung cancer patients of all sexes survived less than five months each. The data on deaths and survival are very significant. These results should encourage our health care system to pay more attention to notification systems and effective prevention measures, in particular, tobacco control, promotion of healthy eating habits, regular physical activity, and screening for breast, cervical, and colorectal cancer..