: To study the effect of intravenous esmolol on intraoperative analgesic requirements in laparoscopic cholecystectomy under general anaesthesia the study was carried out in 80 patients after obtaining consent from the patients who were divided into two groups, group e (esmolol) and group p (isotonic saline). haemodynamic parameters, fentany lrequirement, concentration of isoflurane used, autonomic signs and somatic signs were monitored intra-operatively an 1hour post-operatively. there was a significant difference between haemodynamic parameters at 1min,5min after intubation, during incision, starting of pneumoperitoneum, 15, 30, 60min of pneumoperitoneum, and 15min after release of pneumoperitoneum between the two groups. Relatively lower values in group were seen and statistically noteworthy difference was found (pvalue<0.05). Relatively lower requirement of fentanyl, concentration of isoflurane was used and relatively lower autonomic and somatic signs was seen in group E and the difference was found to be statistically noteworthy (pvalue<0.05). The hemodynamic parameters in control group after supplementing with fentanyl and increased concentration of isoflurane were similar to those who received esmolol. thus, esmolol having analgesic property can be given a thought. hence, we conclude that the intraoperative use of esmolol attenuated nociceptive stimulation..