International Medical Journal

Journal ID : IMJ-29-12-2019-106

Total View : 488

Title : Use of immunohistochemistry and silver in situ hybridization (SISH) in evaluation of human epidermal growth factor receptor2 (HER2/neu) status in Iraqi patients with breast cancer

Abstract : Breast cancer is the commonest cause of cancer-related death in women worldwide. Amplification or over-expression of the ERBB2 (HER/neu) gene occurs in approximately 15-30% of breast cancer cases and it is strongly associated with an increased disease recurrence and a poor prognosis. Determination of HER2/neu status is crucial in the treatment plan as that positive cases will respond to trastuzumab therapy. It has been used to test for HER2/neu by immunohistochemistry as a first step and then to study only the equivocal positive cases (score 2+) by in situ hybridization technique. The aim of our study is to compare between immunohistochemistry and silver in situ hybridization (SISH) in the assessment of human epidermal growth factor (HER2/neu) receptors status among breast cancer patients. A cross-sectional study was conducted at The Medical City in Baghdad, from October 2016 to April 2017, where formalin-fixed, paraffin-embedded tumor tissue from 52 female patients (aged 33 to 71 years) with the diagnosis of breast cancer has been included in this study for the evaluation of human epidermal growth factor (HER2/neu) protein overexpression and gene amplification by immunohistochemistry and silver in situ hybridization (SISH) method respectively. Baseline data about patients were obtained from their hospital records. The distribution of human epidermal growth factor (HER2/neu) protein overexpression by immunohistochemistry showed that the (+2) score/equivocally positive was seen in 24 cases, which comprise the largest number of cases in this study (46.15%). Ten cases (19.23%) for each of the scores 0/negative and +1/negative were present, while (+3) score/positive was the smallest group with only 8 cases (15.38% of cases). All results of SISH were negative in the category of (0 score/negative). On the contrary, all the 8 cases in (+3 score/positive) category were showing positive SISH results. Category (+1 score/negative) HER2 showed two cases (20%) with a positive SISH result, while that of (+2 score/equivocal positive) showed 8 positive cases (about 33.33%). For the detection of HER2/neu protein overexpression and gene amplification, immunohistochemistry (IHC) and in-situ hybridization (ISH) are the recommended techniques, with high concordance between the two techniques, however; performance of silver in situ hybridization in assessment of HER2/neu gene status in all cases of invasive breast carcinoma is recommended as significant number of negative cases by immunohistochemistry showed positive amplification by in situ hybridization and can be treated with anti-HER2 targeted treatments.
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International Medical Journal

Journal ID : IMJ-29-12-2019-105

Total View : 610

Title : Using the Self-Esteem Scale of Toulouse to assess the Psychological Traumatized Self-Esteem of Children living in the Incomplete Families: A Concern for children’s Mental Health in Vietnam

Abstract : The article reported the effects of the psychologically traumatized self-esteem of children living in incomplete families. Assessing by 336 parents who had divorced or lived in single families, the Self-Esteem Scale of Toulouse was used to measure the self-esteem of children with psychological trauma in incomplete families and find the correlation between the five selves in the self-esteem. The results showed that there is difference in the self-esteem of “Physical Self”, “Academic – Future Self”, “Emotional Self”, “Family Self”, and “Social Self” between three groups of children with “no psychological trauma”, “children at the boundary state” and “children with psychological trauma in incomplete families.” With both positive and negative correlation among the five selves in the self-esteem of children who had psychological trauma caused living in the incomplete family, it could be provided some mental support (psychotherapies) for each traumatized self to maintain stable mental health for children in Vietnam.
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International Medical Journal

Journal ID : IMJ-29-12-2019-104

Total View : 258

Title : University Educators' Attitudes towards Using Rubrics in Assessing Students' Performance

Abstract : Most often assessing students' performance offers meaningful learning experiences to educators who take part in this process as well as for students. The main objective of the current survey was to investigate university's educators' attitudes towards using rubrics in assessing students' performance. This was a cross-sectional, non-experimental research design that carried out on a representative sample of male and female university teaching staff at Najran University, during the period from January, 2019 to October, 2019. By adopting a purposive sampling technique, a total of 146 faculty members from two major studying fields (medical & non-medical) had been recruited to participate in the current study. A structured self-administered online questionnaire was utilized for collecting data. The findings revealed that the majority (60%) of the respondents have positive attitudes towards using rubrics as tools for assessing the students' performance. Additionally, the results show that there were no significant differences among faculty teachers attributed to their academic titles (P-value= 0.514) as well as to their years of experience (P-value =0.668). In contrast, a significant statistical difference between faculty members attributed to their gender (P-value = 0.001*) as well as to their department affiliation (P-value = 017*) in favor for the medical staff respectively. The key findings show that rubrics make the assessment process more valid and reliable; therefore, would be significant tools for assessing students' performance as well as the possibility to facilitate valid judgment of complex competencies.
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International Medical Journal

Journal ID : IMJ-29-12-2019-102

Total View : 494

Title : Predictors of Compassion Satisfaction among Nurses and Midwives

Abstract : Compassion satisfaction (CS)is considered one of the positive effects on quality of life. While Burnout (BO) and Compassion fatigue (CF) are considered from the negative effects of working in the medical field. This study predicted the CS from Burnout (BO) and Compassion fatigue and demographic characteristic among nurses and midwives in gynecological and obstetric units in Jordan. Descriptive, correlational, cross-sectional study using a convenience sample for 105 nurses and midwives from gynecological and obstetric units from three hospitals in Jordan. By answering the professional quality of life scale, version 5 (ProQOL-V scale) and demographical characteristic sheet. 12.8 % of the Compassion satisfaction levels might be predicted by the Burnout level. Burnout, Compassion fatigue, and Compassion satisfaction were at an average level (47.6%), (42.9%) and (46.7%) of the participants respectively. There was a positive relationship between levels of Burnout and Compassion fatigue, and the negative relationship between levels of Burnout and Compassion satisfaction. Marital status, educational level, health sector, and work shift-type had had a significant correlation with Burnout, Compassion fatigue and Compassion satisfaction. The average levels of Burnout, Compassion fatigue and Compassion satisfaction for nurses and midwives in gynecological and obstetric units are considered similar to other hospital units. Predictors of compassion satisfaction are highlighted for the nursing administrators to give more attention to these factors.
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International Medical Journal

Journal ID : IMJ-28-12-2019-101

Total View : 644

Title : The Role of Interleukin-10 rs.1800896 and Interferon-Gamma rs.2430561 Single Nucleotide Polymorphisms in Multi-Drug Resistant Tuberculosis

Abstract : Multi-drug resistant tuberculosis (MDR-TB) represents a major public health problem on a global scale so the aim of this study was to determine the association of Interleukin-10 (IL-10) rs.1800896 and Interferon-Gamma (IFN-γ) rs.2430561 single nucleotide polymorphisms (SNP) with MDR-TB. 60 tuberculosis patients (30 patients with and 30 patients without MDR-TB) and 30 healthy subjects as controls participated in this study. Serum IL-10 and IFN-γ levels were measured by ELISA. SNPs of IL-10 –rs.1800896 and IFN-γ rs.2430561 genes were detected using allele-specific amplification. IL-10 serum level was significantly higher in TB patients with MDR (57.3±14.8 pg/l) than TB patients without MDR (41.5±8.4 pg/l). Serum IFN-γ was significantly lower among TB patients with MDR (41.7±15.8 pg/l) compared to TB patients without MDR (83.7±25.05 pg/l). The AA genotype of IL-10 rs.1800896 and TT genotype of IFN-γ was significantly higher in the control group than in patient groups. Also The AA genotype of IFN-γ rs.2430561 was significantly higher in patient with MDR than in patient without MDR-TB. Regarding IL-10 GG and AG genotypes was considered risk from MDR TB (OR=11.54 and 4.1 for GG and AG respectively). Regarding INF-γ TT and AT genotypes considered protective for MDR TB (OR=0.09 and 0.17 for TT and AT respectively).
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Submission Deadline ( Vol 30 , Issue 09 )
20 Sep 2023

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Publish On ( Vol 30 , Issue 07 )
31 Jul 2023