: Compassion satisfaction (CS)is considered one of the positive effects on quality of life. While Burnout (BO) and Compassion fatigue (CF) are considered from the negative effects of working in the medical field. This study predicted the CS from Burnout (BO) and Compassion fatigue and demographic characteristic among nurses and midwives in gynecological and obstetric units in Jordan. Descriptive, correlational, cross-sectional study using a convenience sample for 105 nurses and midwives from gynecological and obstetric units from three hospitals in Jordan. By answering the professional quality of life scale, version 5 (ProQOL-V scale) and demographical characteristic sheet. 12.8 % of the Compassion satisfaction levels might be predicted by the Burnout level. Burnout, Compassion fatigue, and Compassion satisfaction were at an average level (47.6%), (42.9%) and (46.7%) of the participants respectively. There was a positive relationship between levels of Burnout and Compassion fatigue, and the negative relationship between levels of Burnout and Compassion satisfaction. Marital status, educational level, health sector, and work shift-type had had a significant correlation with Burnout, Compassion fatigue and Compassion satisfaction. The average levels of Burnout, Compassion fatigue and Compassion satisfaction for nurses and midwives in gynecological and obstetric units are considered similar to other hospital units. Predictors of compassion satisfaction are highlighted for the nursing administrators to give more attention to these factors.