: The relationship between cytokines and dyslipidemia, obesity and hypertension are of great importance in the pathophysiology and progression of metabolic syndrome (MetS). This study aims to investigate the association of five cytokines with the accumulation of metabolic disorders including; dyslipidemia, obesity and hypertension. A total of 50 healthy individuals and 100 patients with MetS have been enrolled. Based on MetS biomarkers, eligible patients were divided into two groups; group 1; obese + dyslipidemic patients and group 2; obese + dyslipidemic and hypertensive patients. The results showed a marked increase in the level of leptin, interferon-γ (IFN-γ), interleukin-17 (IL-17) as well as expression of interleukin-6, (IL-6), but a decrease in the expression of interleukin-10 (IL-10) level was recorded in both MetS groups relative to healthy controls. Additionally, the results revealed a higher frequency of the IL-17A/A homozygote polymorphism in MetS patients. Among group 1, the recorded values of MetS patients showed a positive correlation between leptin with obesity and IL-17 and a negative correlation between IL-10 and obesity. Regarding group 2, leptin recorded a positive correlation with dyslipidemia, while IL-17 exhibited a positive correlation with blood pressure, obesity, and dyslipidemia. On the other hand, IL-10 observed a negative correlation with blood pressure, obesity, and dyslipidemia. Therefore, leptin, IFN-γ, IL-17, IL-6, and IL-10 were associated with the MerS biomarkers and linked to the pathophysiology mechanisms of MetS component pathophysiology and development. Notably, understanding of these pathways would help the development of anti-inflammation therapeutic strategies..