: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is the strain of corona virus that causes corona virus disease2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Diabetes mellitus is a major public health problem in of the 21st century. Our study aimed to study Covid-19 related diabetes and try to find predictors of mortality in these patients. This retrospective observational study evaluated 500 COVID-19 confirmed patients hospitalized at Minia University Hospital. The patients were classified to two groups based on FBG and HbA1c levels as follow: Group (I) Non-diabetic patients, Group (II): Newly diagnosed diabetic patients. Then, every group was divided into two subgroups as follow, discharged alive group and died cases group and these subgroups were compared. Follow up of newly diagnosed diabetic patients discharged alive was done after 3 months by FBG and HbA1C. Comparison between the two group revealed significantly higher symptoms, chest signs, COVID markers and poor outcome in group II of newly diagnosed diabetes. Independent significant predictors of the presence of newly diagnosed DM among COVID-19 patients are Older age, higher BMI, lower lymphocytes, elevated COVID markers and lower SpO2. Independent significant predictors of mortality in DM group are higher BMI, elevated COVID markers and lower SpO2. The newly diagnosed DM persisted for three months in about 76.6% of affected subjects. We demonstrated a significant proportion of COVID-19 patients developed new-onset DM which often persist and this was accompanied by more severe infection and higher mortality..