Abstract : This study evaluates the effects of selected irrigants; the distal water (control), apple vinegar, sodium hypochlorite (NaOCl), ethylenediamine tetra-acetic acid (EDTA) and diode laser on root canal dentin minerals as ca, phosphorus, Mg and Na ions. Human canines(n=50) were instrumented by #30 stainless steel file and the final irrigation was performed with apple vinegar, 17% ethylenediamine tetra-acetic acid (EDTA), diode laser irradition (980nm), sodium hypochlorite (NaOCl) and distilled water (control), which were analyzed by atomic absorption spectrometry to determine the concentration of calcium ions, phosphers ions, magmisim ions, and sodium ions by edex. Statistical analysis was performed which set at P ≤ 0.05, in ca ions: the (EDTA and Na) groups showed highest value, while (Vinegar, Na and Laser) groups showed less value. In Mg ions: (EDTA and Na) groups showed highest value, while (Vinegar, Na and Laser) groups showed the less value. In Na ions: (EDTA, Na ad Laser) groups showed the highest value, while the less value was found in (Vinegar, Na and Laser) groups. In Ph ions: (EDTA and Na) groups showed highest value, while the less value was found in (Vinegar, Na and Laser) groups. The diode laser in combination with apple vinegar might be used as a final management of the root canal system before canal obturation due to its chelating effect than EDTA.