Hemodialysis is beneficial for patients with chronic renal failure but has side effects. Hemodialysis patients should be able to maintain an interdialytic bodyweight < 1.5 kg to minimize intradialytic complications. This study was to deter- mine the relationship between gender, age, duration of hemodialysis with interdialytic weight gain (IDWG) and complications of intradialytic at Panembahan Senopati Hospital, Bantul, Yogyakarta, Indonesia. This research was an analytic observational quantitative study with a cross-sectional design. The sample in this study were 132 patients at Panembahan Senopati Hospital, Bantul. The sampling technique used consecutive sampling. The instruments were weight scales, IDWG observation sheets and intradialytic complications observation sheets. Bivariate analysis using the Somers test. Most of the respondents were male (54.5%), taking blood pressure drugs (78.0%), the late elderly (31.1%), and undergoing hemodialysis > 24 months (76.5%). The majority of respondents experienced increased IDWG and mild complications. Bivariate analysis between sex, age, and duration of HD with IDWG were p0.963, p0.568, and p0.608. The bivariate test results between sex, age, HD duration, and IDWG with intradialytic complications were obtained p0.551, p0.980, p0.417, and p0.001. There was no association between sex, age, and duration of HD with IDWG and intradialytic complications, whereas changes in IDWG were associated with intradialytic complications.