International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal.

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-04-02-2020-203
Total View : 149

Abstract : The purpose of the study was to investigate the immune response in patients with recurrent pyelonephritis depending on the presence of hyperoxaluria.The observational cross-sectional study involved 64 women with recurrent pyelonephritis. The patients’ immune response was evaluated by determination of serum concentrations of interleukins (IL) -4, -17, -18, -23, tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein 1 (MCP-1). Depending on the presence of hyperoxaluria (urinary oxalate excretion was more than 0.45 mmol per day), the patients were allocated into 2 groups: the women with hyperoxaluria were included to group I (n = 35) and the patients with normal levels of oxalate excretion were included to group II (n = 29). The control group consisted of 25 practically healthy donors.The mean age in the patient population was 31.6 ± 7.7. The average number of pyelonephritis recurrence was 6.4 ± 1.9 per year. We identified a moderate direct correlation between the levels of the urinary oxalate excretion and the number of pyelonephritis recurrences per year (r = 0.71, p < 0.0001) and the inverse strong correlation between oxaluria and GFR level (r = 0.75, p < 0.0001). The patients with hyperoxaluria had increased synthesis of the blood concentration of TNF-α, MCP-1, IL -4, -17 and 23. Our results have provided preliminary evidence that hyperoxaluria is associated with increased serum levels of IL-4, -17, -23, MCP-1 and TNF-α. The larger-scale studies are needed for further confirmation of our findings.
Full article
International Medical Journal
Journal ID : IMJ-04-02-2020-202
Total View : 163

Abstract : Obesity is an excess of body fat and characterized by adipose tissue dysfunction causes an increase in proinflammatory adipocytokines, including C-Reactive Protein (CRP). Studies have shown the increasing of CRP levels in obese patients. C-reactive protein can cause left ventricular remodeling by myocyte biological remodeling, myocyte apoptosis and degradation of extracellular matrix which cause changes in myocardial mechanics and changes in left ventricular systolic function. This study aims to investigate the hs-CRP as a marker of subclinical left ventricle (LV) systolic dysfunction in young adults with obesity. This study was conducted in a single center with cross-sectional design to all young adults with obesity that worked in Hasan Sadikin General Hospital, Bandung, during August-November 2019. The inclusion was subject with normal ejection fraction (EF) > 50%. We excluded subject with poor echocardiography window, cardiac rhythm other than sinus rhythm, diabetes mellitus, hypertensive heart disease, history of coronary artery disease, congenital heart disease, valvular heart disease, dilated cardiomyopathy, restrictive cardiomyopathy, hypertrophic cardiomyopathy, pericardial disease, myocarditis, heart failure, infection, inflammatory disease , necrotic condition, malignancy, statin consumption, and dyslipidemia. Hs-CRP was measured by particle enhanced turbidimetric assay. Left ventricle function was measured by Global Longitudinal Strain (GLS) with speckle tracking echocardiography technique, performed by 2 independent examiners. The correlation between hs-CRP and GLS was analysed using Pearson correlation. A total of 29 patients (69.0% male, 30.55 + 5,38 years old) included in this study. The average of hs-CRP level was 8.8 (1.07 – 35.1) mg/L and the average of GLS was -19.18 ± 0.72%. After data log transformation of hs-CRP, there was a significant negative correlation (r= -0,542, p=0,001) between the hsCRP and GLS in young adults with obesity. Increasing hs-CRP level may predict subclinical LV systolic dysfunction in obese young adults with no other comorbidities.
Full article
International Medical Journal
Journal ID : IMJ-04-02-2020-200
Total View : 100

Abstract : Nocturnal enuresis is one of the most common problems among children, which can be along with family concerns and mental disorders. Although the cause of nocturnal enuresis is not well identified, but one of the discussed causes is Adenotonsillar hypertrophy, which causes upper airway obstruction and sleep apnea in 3-10 years old children. The present study is a cross-sectional-descriptive-analytical study, which performed in Khatamolanbia Hospital in Zahedan. The study sample consisted of 250 children with Adenotonsillar hypertrophy, who ranged in age from 3 to 10 years. Data analysis were done using descriptive statistics including statistical tables and charts and analytical analyzes by chi-square test. Among the 250 patients with Adenotonsillar hypertrophy with an average age of 2.40 ± 6.43, 64.4% of patients had nocturnal enuresis. There was a significant relationship between the severity of tonsillar hypertrophy and nocturnal enuresis at Brodsky scale (P <0.001). Also, family history is one of the factors that affecting the nocturnal enuresis of children (001/0> P). The reviews showed well that nocturnal enuresis is highly prevalent in children with Adenotonsillar hypertrophy and those children whose parents had a history of nocturnal enuresis in childhood, are more likely to suffer from this problem.
Full article
International Medical Journal
Journal ID : IMJ-04-02-2020-199
Total View : 174

Abstract : A.actinomycetemcomitans are pathogenic bacteria that cause damage to periodontal tissue so that it is clinically seen as a periodontal disease (periodontitis). There are no studies that report bacterial load after the use of purple miana leaves extract (PMLE) in Periodontitis. This research objective was to determine the effect of purple miana leaves extract on bacterial load in wistar rats that have been induced by A.actinomycetemcomitans. Rats were divided into three groups, purple miana leaves extract (PMLE) 510 mg/ kgbw, negative control (aquadest), antibiotic levofloxacin 500 mg/kgbw as positive control. Samples of A.actinomycetemcomitans bacteria were taken seven days after induction of 3x108 cfu/ml A.actinomycetemcomitans in gingival sulcus of the anterior mandibular teeth of the rat/after periodontitis (D8) and seven days after intervention (D15). Bacterial load is measured by calculating colony forming units. The results obtained are processed using SPSS. Bacterial load on D8 to D15 had a different pattern between the PMLE group, the aquades group (negative control) and the levofloxacin group (positive control). In negative controls, an increase in bacterial load but not significantly different (p>0.05). In PMLE and positive control, there was a decrease in bacterial load and significantly different (p<0.05). Purple miana leaves extract (PMLE) 510 mg/kgbw and levofloxacin 500 mg/kgbw successfully suppressed the growth of A.actinomycetemcomitans (bacterial load) colonies for 7 days of use.This study represents that PMLE can be an alternative drug in patients with A.actinomycetemcomitans infection, especially in the case of periodontitis.
Full article
International Medical Journal
Journal ID : IMJ-04-02-2020-198
Total View : 292

Abstract : Smoking epidemic remains to be one of the biggest public health issues the world has ever faced. Cigarette smoke can stimulate peroxidation of lipid and oxidation of proteins and become a risk factor for atherosclerosis and cardiovascular disease. Aloe vera has been used for medicinal purposes for centuries and reported to have potent antioxidant capacity. Considering its good potential as alternative medicine in the future, this study aimed to evaluate the effect of Aloe vera on serum lipid profile in the rat after being exposed to cigarette smoke. The experimental study was conducted on male rats which were divided into 3 groups. The first group was a control, the second group was exposed to the smoke of 8 cigarettes/ day for 30 minutes. The other group was given 1 mL/ day of Aloe vera gel an hour before the exposure of the smoke for 42 days. The blood sera were measured for lipid profile, consisting of total cholesterol, low density lipoprotein (LDL), and high density lipoprotein (HDL). The results were statistically analyzed using Kruskal-Wallis and post hoc test Mann-Whitney. There was a significant increase in serum LDL and a decrease in HDL between control and cigarette smoke group (p<0.05). A comparison of results between cigarette smoke and cigarette smoke plus Aloe vera groups showed a decreasing concentration of serum LDL (p<0.05). Aloe vera L. may prevent dyslipidemia in rats after being chronically exposed to cigarette smoke.
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