: Grip strength is a simple tool used to rapidly assess muscle strength. It can provide diagnostic information and be used to assess clinical outcomes. The purpose of this study was to find out an equation that could predict hand-grip strength in relation to age, weight, height, mid upper arm circumference, hand length and hand span in Egyptian healthy mid-adolescents. Two hundred and forty volunteer healthy adolescents of both sexes participated in this cross sectional study. Their Body Mass Indices (BMI) followed normal values. EuroQol 5-Dimension Questionnaire for youth (EQ-5D-Y) was applied to determine participant’s health status. A JAMAR plus hand held dynamometer was used for measuring handgrip strength. Independent t-test, Pearson correlation co-efficient and Linear regression equation were used (p<0.05). We found positive correlation between handgrip strength and all measured parameters. Also, hand-grip strength could be predicted according to age, weight, height, mid upper arm circumference, hand length and hand span. we demonstrated that, hand-grip strength is positively correlated to general and anthropometric characteristics in Egyptian healthy mid adolescents.