International Medical Journal

Journal ID : IMJ-12-01-2022-1191

Total View : 465

Title : Evaluation Of Kidney Function In Children Aged 5-18 Years with Sickle Cell Anemia

Abstract : To assess the renal function in children with sickle cell disease and to find the prevalence of micro-albuminuria in sickle cell anemia. It was a single-center, cross-sectional, descriptive study of all children aged 5-15 years with sickle cell anemia. The study population included children diagnosed with sickle cell anemia by hemoglobin electrophoresis (HPLC) having an SS pattern. All relevant demographic details like age, gender, residence were noted. Detailed clinical history of each patient and history of hospital admissions, number of hospitalization, number of blood transfusions was noted. Physical examination and anthropometry were noted. Significant proteinuria (> 1+ by dipstick) was seen in 21(33%) of study subjects. The estimated glomerular filtration rates were within normal limits in 52 (81%) of study subjects and the rest 12(19 %) study subjects had hyperfiltration (GFR > 2SD). As significant proteinuria is an early marker of impairment of kidney function in children with sickle cell disease, Proteinuria screening should be done early and should be regularly assessed so as to detect early kidney damage. There was no evidence of chronic kidney disease. There was no evidence of change in pH/Hypokalemia/ Metabolic Acidosis s/o tubular dysfunction..
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International Medical Journal

Journal ID : IMJ-12-01-2022-1189

Total View : 421

Title : LIVER FUNCTIONS IN CHILDREN WITH DENGUE FEVER

Abstract : This study was conducted to understand the abnormalities in liver functions in children with Dengue fever and its associations with the outcome. The aim of this study was to assess liver functions SGOT (AST) & SGPT(ALT), Serum Albumin in children with Dengue fever. To study the association of liver function tests with clinical stages of dengue fever and outcome with the severity of liver enzymes. This Prospective study was conducted in Paediatric wards of NKPSIMS & LMH, Nagpur from 1st January 2019 to 31st December 2019. During the study period 124 children in the age group upto 18 yrs presenting with fever and positive serology for dengue were included in the study. Children who were diagnosed as Dengue like illness but were serologically negative and those with cirrhosis, chronic liver disease or concomitant infection with malaria, Hepatitis A, Hepatitis B, enteric fever were excluded from the study. During the one year study period 124 children were admitted as serologically positive dengue patients. Among them 80 (64.51%) were male and 44(35.46%) were female. Maximum children were in age group of > 5yrs. Patients with dengue fever without warning signs were 73(58.87%), 44(35.48%) were dengue with warning signs and 7(5.65%) were cases of severe dengue. The SGOT(AST) levels were more than 300 in 22.8% while SGPT (ALT) levels were raised in only 2.41%. Out of the 28 children with SGOT (AST) levels > 300IU/L 28.57% of children had serum albumin levels <2.5g/dl. Patients with SGOT (AST) & SGPT (ALT) levels of more than 300IU/L had hospital stay of more than 7 days. Of the total 28 patients who had SGPT(AST) levels more than 300U/L, 6 (21.42%) patients had complications in the form of ascites and pleural effusion and 2 (7.14%) patients had severe bleeding. The mortality rate in our study was 0.08%. Liver Function Tests derangements are seen in all forms of dengue fever. Higher SGOT (AST) levels as compared to SGPT (ALT) were seen in patients with severe Dengue which was also associated with prolonged hospital stay. A significant rise of liver enzymes helps in the recognition of severe forms of dengue infection..
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International Medical Journal

Journal ID : IMJ-12-01-2022-1188

Total View : 415

Title : Spontaneous Intracranial Hypotension: A Case Report and Review of Literature

Abstract : Spontaneous intracranial hypotension (SIH) is a syndrome characterized by orthostatic headache, low cerebrospinal fluid (CSF) pressure and diffuse pachymeningeal enhancement on brain magnetic resonance imaging (MRI). With advancements in imaging techniques, increased instances of SIH have been reported. We present a case of a 33-year-old man presented with SIH. An epidural blood patch at the lumbar level was performed. The patient had atypical chronic mood and behavioural symptoms with subacute onset of postural headache and tinnitus. Though MRI spine did not detect a CSF leak, there was subdural fluid collections and he responded well to an epidural blood patch done at the lumbar level. His headache and tinnitus gradually recovered over a period of two months. Whereas mood and behavioural symptoms improved at a slower rate. An epidural blood patch seems to have an advantage in SIH despite absence of a CSF leak..
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International Medical Journal

Journal ID : IMJ-11-01-2022-1183

Total View : 397

Title : A STUDY OF HELICOBACER PYLORI INFECTION IN PERFORATED PEPTIC ULCER AND ASSOCITED RISK FACTORS

Abstract : Peptic ulcer disease is a global problem with a lifetime risk varying from 5-10%. Peptic ulcers are defined as erosions occurring in duodenal or gastric mucosa which extends into the muscularis mucosa. Approximately 80-90% of peptic ulcers are associated with H.Pylori infection and the identification of H.Pylori as a prominent risk factor for PUD has revolutionized our understanding of the etiopathogenesis of peptic ulcer disease. This study was taken up to evaluate the prevalence of H. pylori infection in patients with acute perforated peptic ulcers in patients admitted in a tertiary care centre. This study also aims to highlight other overlapping risk factors associated with peptic ulcer perforation. The Mean age of 30 study sample was 48.07 years (standard deviation – 11.65 years. History of NSAIDs intake (11), spicy food (9) were also present in some subjects. Some subjects were having more thaan one risk factor among study samples. H pylori was present in 5 out of 12 gastric perforation subjects and 8 out of 18 duodenal perforation subjects on histopathology. Among 30 cases 13 (43.3%) were confirmed to be positive for H.pylori infection and among those 13 cases only 5 ( Sensitivity : 38.46% ) cases had positive for urease test and 3 ( Sensitivity : 23.07% ) showed growth on culture media. This study shows that there is a positive correlation between H.pylori infection and acute perforated peptic ulcer. The incidence of H.pyori however has reduced over the past decade which could be due to over the counter use of H.pyori eradication therapy or we need to evolve more sensitive modalities for detecting H.pylori. in low bacterial count cases..
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International Medical Journal

Journal ID : IMJ-10-01-2022-1182

Total View : 357

Title : A COMPARATIVE STUDY BETWEEN SILVER COLLOID ASSISTED WOUND CLOSURE VS CONVENTIONAL DRESSING IN NON HEALING ULCERS

Abstract : All patients admitted with clinical diagnosis of “Diabetic or Non-Healing ulcers or traumatic ulcers” under General Surgery care in SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE were taken as Subjects for this study with a sample size of 116 in each group based on previous study. After initial assessment of wound as per the PUSH criteria (Pressure Ulcer Scale of healing) initial wound debridement was done and in silver Nano group ulcer were treated with silver Nano colloid gel and in conventional group ulcer are treated with saline. Patients were then subjected to regular investigations and dressings. The wound was assessed as per PUSH scale for a period of 8 weeks. Wound score was noted at 2nd, 4th, 6th and 8th weeks of the study and the data collected were evaluated statistically with p value less than or equal to 0.05 as an indicator of statistical significance. After treatment, in silver nano group, wound score is 4.20 and in conventional group it is 6.88. There is statistically significant association between two groups with respect to wound score (P=0.01). The two groups are similar with respect to wound area at baseline,2 weeks and 4 weeks. They differ statistically with respect to wound area at 6 weeks and 8 weeks (P=0.01). Amount of exudate is similar in both the groups at baseline. They differ statistically at 2,4,6th and 8th week. Amount of exudate is less in the silver nano group compared to conventional group. The two groups are comparable with respect to type of tissue at base line and second week. They differ statistically at 4th, 6th and 8th weeks. There is early granulation followed by rapid epithelisation in silver nano group compared to conventional group. The percentage reduction in score as per PUSH scale is calculated. In silver nano group 74.40 reduction score and in conventional group it is 60.80 which is of statistical significance. Mean duration of hospital stay was significantly less in silver nano group compared to conventional group. In Present study to assess the role of silver nano colloid in treatment of diabetic ulcer we conclude that silver nano colloid particles are effective in treating patients with diabetic ulcers than that of conventional dressings in terms of wound size, exudate amount, and tissue type.".
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International Medical Journal

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Submission Deadline ( Vol 30 , Issue 09 )
20 Sep 2023

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Publish On ( Vol 30 , Issue 07 )
31 Jul 2023