: Centella is a bioactive-rich medicine plant in Viet Nam and essential for a healthy life. Phytochemistry composition (triterpenoid, polyphenol, chlorophyll), nutrition components (fat, carbohydrate, protein, fiber), vitamins (ascorbic acid, thiamine, pyridoxine, cobalamin, beta carotene), minerals (Total of minerals, Mg, Ca, Fe, P, Na, K, Cu, Mn, Cr, Zn) and antioxidant activities of Hydrocotyle asiatica, Hydrocotyle verticillata, and Hydrocotyle javanica, were analyzed in the study. The results ranged as follows; fat (2.83 - 5.23) %, fiber (41.32 – 46.21) %, protein (11.32 - 12.21) % and carbohydrate (23.32 – 28.42) %. Ascorbic acid, thiamine, pyridoxine, cobalamin, and beta carotene content varied from 46.12 to 73.22, 0.93 to 1.35, 0.64 to 0.81, 0.21 to 0.34, and 26.11 to 29.31 mg/100g DW. Polyphenol, triterpenoid, and chlorophyll content varied from 6.093 to 13.557 mg gallic acid equivalent, 2.927 to 5.90 mg oleanolic acid equivalent, and 3.428 to 4.731 mg per g DW. The mineral elements ranged from 3.62 to 4.14 mg/100g DW) and consisted of magnesium, calcium, iron, phosphorus, sodium, potassium, copper, manganum, chromium, zincum. The results suggest that three species of Hydrocotyle in the current study could provide necessary nutrition for the normal growth and against diseases causing malnutrition. Hydrocotyle asiatica can provide good phytochemistry compositions for application to functional foods and pharmaceutics..