International Medical Journal

This study aimed to evaluate podcast as an alternative learning media for primary survey skills in medical students at Atma Jaya University. One group pretest-posttest design on 54 clinical clerkship students in surgery rotation and the pretest and posttest results were compared. A podcast about the primary survey was made and given to students after the pretest. An assessment sheet for the scoring of primary survey skills was used in pretest and posttest to measure the students primary survey skill knowledge. The change between tests’ scores was used to measure the students' skill knowledge improvement. A follow-up survey was also given for the students' opinions. There was a statistically significant increase in the primary survey knowledge between the pretest and posttest using a podcast as a learning media. The majority of students had an interest in learning using podcast media, increased their desire to learn, and interested in reading further primary survey theories. Podcast is effectively used as a learning media for primary survey in medical students at Atma Jaya University. Students had an interest in learning with podcast media and reading further theories about the primary survey.

There have been no naturalistic reports in Japan clarifying the effect of switched to emborexant on insomnia disorder. This study aimed to investigate the difference in treatment continuation between the recently started group and switched group in clinical setting. Insomnia was assessed using the Athens Insomnia Scale (AIS). Efficacy outcome assessment was the Clinical Global Impressions-Improvement scale (CGI-I). 77 patients had recently started lemborexant and 73 patients switched from benzodiazepine hypnotic monotherapy to lemborexant. The mean AIS total score of the recently started group and switched group were a significantly improved (7.7 ± 4.1 to 3.7 ± 3.4; 5.7 ± 3.3 to 3.9 ± 3.3) (p < 0.05). There was no significant difference in the mean CGI-I scale between the recently started group and switched group (3.0 ± 0.9; 3.3 ± 0.8). Furthermore, there was no significant difference in the 24-weeks continuation rate between the recently started group and switched group. These results indicate that the use of lemborexant may lead to safe and maintenance therapy, which is one of the exit strategies for hypnotics, and may in turn improve drug adherence.

I analyze the sexography of Wardell Pomeroy (1913-2001), a junior collaborator of Alfred Kinsey in case history collection and the 2nd author of the two landmark volumes of 'Human Sexual Behavior published in 1948 and 1953 respectively. Pomeroy's oeuvre (books, book chapters and journal articles) was studied. Pomeroy was a clinical psychologist with a PhD from Columbia University in 1954. A total of 31 items, published between 1948 and 1990 included 9 books, 7 book chapters, 1 foreword to a book on tattoos, and 14 journal articles of miscellaneous variety. As such, Pomeroy's published productivity was quantitatively less in comparison to that of his junior contemporary physician sexologists William Masters and Alex Comfort. As Pomeroy published only 27 items (including 4 sole-authored books) during his post-Kinsey period, his reputation as a sexuality scholar remains firmly linked with the two Kinsey reports, in which he was the 2nd author. But this hardly dents Pomeroy's impeccable reputation as a pioneering sexologist of mid-20th century.

Dental anomalies are the formative defects that occur as a result of multifactorial interactions between genetic or environmental factors during the process of tooth development. Literature has revealed presence of multiple dental anomalies such as supernumerary tooth, tooth agenesis, ectopic tooth eruption, atypical tooth size or shape, taurodontism, pulp stones etc in various syndromic or non-syndromic conditions. Although asymptomatic, but early diagnosis is requisite for better patient management to prevent the occurrence of associated complications. Here, we report a rare case of 23-year-old male patient who presented with cardiovascular manifestations along with multiple dental and skeletal findings. Such combination of dental and skeletal findings has not been reported earlier in association with any individual syndrome. Hence, we propose it to be a new syndrome of non-genetic type associated with multiple cardiac, skeletal and dental anomalies.

The present study aims to evaluate the relevance of IFNλ4rs73555604 SNP and ERAP1rs26618 SNPs and response to direct anti-viral drugs among HCV infected Egyptian patients. 100 participants were included in the study (40 HCV infected patients responded to DAA therapy, 40 HCV infected patients who did not respond to DAA and 20 healthy volunteers). Allelic discriminations of IFNλ-4 rs73555604SNP and ERAPrs26618SNP were carried out using step One real-time PCR. Allelic discrimination of IFNλ4rs73555604 and ERAP1rs26618 exhibited significant differences among the studied groups where 75% of non-responders carry IFNλ4rs73555604T allele while 75% of responders carry ERAPrs26618C allele. Calculations of odds ratio revealed that persons carrying T allele of INFλ4rs555604 and ERAPrs26618 have 2.5 and 3.3 folds more odd to be non-responder to DAA therapy, respectively. IFN-λ-4rs73555604 and ERAP-1rs26618 polymorphism could affect HCV response to DAA treatment among HCV infected Egyptian patients. There was a significant association between INFλ4rs555604CC genotype and response to treatment. However, ERAP1rs26618T-allele was associated with resistance to treatment. Odds ratio calculation revealed that persons carrying ERAPrs26618T allele have 3.3 folds more odd to be non-responder to DAA therapy. Both SNP can be used as surrogate markers to assess response to DAA treatment.