: Morocco places the fight against cancer as a national health priority; however, the exploitation of existing data in this field is rare because of a fragmentary, incomplete and deficient routine information system. This observation is valid for the region of Marrakech Safi, which does not yet have its own cancer registry, allowing it to know the epidemiological profile of this pathology. Retrospective descriptive and analytical epidemiological study at the center of oncology and hematology of Marrakech from the records of patients with cancer diagnosed between January 2014 and December 2018. The data collection concerned the data related to the variables: sex, age, marital status, origin (city), environment (urban/rural), occupation, mode of payment and management, cancer location. The data were entered and analyzed on SPSS version 24. The incidence of the Marrakech Safi region estimated on the world population is (162.09/100 000) with a female predominance (201.48/100 000) (p<0.0001), against (123.25) for men. Out of 9272 cases of all types of cancer, the risk factors studied show that cancer affects women more than men (62%) (p<0.0001). Their average age is 54.40 ±15.39 years (p<0.0001). The patients are mainly married (80%) (p<0.0001), without profession (84%) (p<0.0001), coming from urban areas (69%) and from the northern provinces of the region. Among the most frequent types of cancer in the female population, breast (43%), cervical (16%), colorectal (6%) and stomach (4%). Among men, lung cancer ranks first (15.5%) followed by prostate (11.9%), stomach (10.6%) and colorectal (10.5%). Whatever the epidemiological indicators used in the analysis of cancer, the situation is very alarming for our country. The establishment of a comprehensive national or regional policy to fight against this scourge requires the installation of cancer registers in the various national oncology centers and the encouragement of research studies in a perspective of the creation of a data portal on cancer in Morocco..