Abstract : To study the clinical profile of thyroid nodule, clinical parameters of solitary thyroid nodules and to correlate between clinical diagnosis and histopathological examination of solitary nodule of thyroid. Study was carry out in the Govt. General Hospital, Nizamabad with Patients with solitary thyroid swelling and those who planned for surgery are included in this study. taken sample size 85 with convenient sampling technique and study done between November 2019 to March 2021. Out of 77 lesions which came as benign by HPE, FNAC was able to diagnose 61 benign lesions and imprint cytology was able to diagnose 65 benign lesions. Thus, in the present study imprint cytology was found to be more sensitive and specific than FNAC in diagnosing benign lesions of thyroid. Solitary nodule of thyroid most commonly in females in the third decade with common presentation of solitary thyroid nodule is swelling in front of neck. Follicular adenoma is the most common pathological variant of solitary thyroid nodule. Imprint cytology was found to be more sensitive and specific than FNAC in diagnosing benign lesions of thyroid.