: The healthcare sector in Saudi Arabia was made efforts especially for nurses in critical care units who care of the unconscious patient to enhance their ability to manage the development of communication skills Aim: Illuminating and Implementing Structured Guide Line for Effective Communication with Unconscious Patients for Nursing Student Research Design: A quasi-experimental design. Setting: faculty of nursing, Njran university. Sample: A convenience sample of (Baccalaureate) nurses. The total number was 60. Tools: two tools, 1st Tool was an interview questionnaire, it divided into two parts .1st part is student demographic data.2ed part is the communication Knowledge Questionnaire: used throughout (pre, and post structured guideline).2ed tool is the communication skills Observational Checklist. This checklist aimed at assessing the actual performance of student nurses regarding their communication. Result: statistically significant difference between students’ knowledge regarding communication with unconscious patients pre and post-intervention, a highly statistically significant difference between students' practice regarding Attitude of communicates with the unconscious patient, there was positive correlation coefficient between student age, level, and their total knowledge and total practice with the unconscious. Conclusion: there were high statistical significant improvements in the knowledge, practice, related to communication skills with an unconscious patient. Recommendation In-service training and education programs must be continuous. Establish standardized training for developing student communication. periodically workshops as needed for nurses about effective communication. preparing for attending of certified training courses in communication with the unconscious patient and general therapeutic communication.