: Thyroid nodules constitute a frequently seen clinical problem, and the incidence of thyroid nodules has increased with the recently increased use of thyroid ultrasonography. Radiofrequency ablation (RFA) is an effective and safe method for treating benign thyroid nodules and recurrent thyroid cancers. A 48 years old woman came with the presence of a painless mass on her neck for the last 20 years. The physical examination measured a mass of 7 x 6 cm, and the laboratory examination showed a euthyroid state. The ultrasound results showed the enlargement of right thyroid (3.1 x 3.3 x 3.5 cm; volume > 20 ml) with increased echo intensity of parenchyma, enlargement of left thyroid (2.6 x 3.4 x 3.4 cm; volume > 16.6 ml) with normal echo intensity of parenchyma, solid lesion ±1.2 cm spongyosa type at left thyroid, and increased vascularization. This mass was concluded as struma nodusa bilateral. The FNAB was follicular neoplasm, Bethesda system class 4. The patient underwent a single session RFA. RFA was performed by transisthmic access using a 7-cm 18-gauge electrode-needle with a 1-cm active needle tip. The procedure was well tolerated by the patient, and no adverse events were noted. Radiofrequency ablation for thyroid lesions is a safe and effective method for treating benign thyroid nodules and even recurrent thyroid cancers. Therefore, various factors including serum TSH, clinical risk factor assessment, size of the nodule, ultrasound characteristics, patient preferences, and results of the FNA biopsy should be considered in the management of thyroid nodules.