: The pressor response to direct laryngoscopy and endotracheal intubation precipitating a significant haemodynamic response is an established phenomenon and thus, a cause of concern for anesthesiologist’s all over the world. Various methods have been tried to counter these effects and increase the safety of the procedure like, use of intravenous local anesthetic agents eg. Intravenous lignocaine, drugs like beta-blockers eg. Esmolol and Metoprolol, narcotic analgesics like Fentanyl, topical lignocaine spray, Gabapentin, alpha 2 agonist drugs like Dexmedetomidine and clonidine intravenously and many more. This current study was planned to compare intravenous lignocaine with intravenous Dexmedetomidine for attenuation of pressor response. a prospective randomized study was carried out on Total 60 patients which were equally, 30 each into Group L and Group D. Group L received injection Lignocaine intravenously 1.5 mg/kg, 3 minutes prior to induction and Group D received injection Dexmedetomidine 1mcg/kg, 10 minutes prior to induction. After analysing the results obtained, it was concluded that injection Dexmedetomidine 1mcg/kg, 10 minutes prior to induction is more efficient when compared to injection lignocaine 1.5mg/kg for attenuation of pressor response to laryngoscopy and endotracheal intubation..