Abstract : Amitraz is acaricide and insecticide for cattle. Poisoning with Amitraz is often confused as organophosphorus (OP) poisoning or carbamates poisoning as Amitraz poisoning has a several clinical features that mimics OP poisoning. Signs like bradycardia, constricted pupils, hyperglycemia, increased respiratory rate are common. A 17 years old female, brought to ER with alleged history of (h/o) con- sumption of Amitraz in an unconscious state i.e.Glasgow Coma Sore (GCS) of 3/15. Patient was intu- bated immediately in view of low GCS and later was shifted to medicine ICU. Management of the patient was a difficult task as very less data and studies are available and there is unavailability of any specific antidote. However, confirmation of Amitraz poisoning is done after retrieval of container. Early clinical evaluation and detail history from both patient and informant is a key for successful management and ex- cellent outcome of treatment.