Abstract : <p>A surgeon is most likely to encounter major salivary gland diseases because of inflammation, stones, tumours or trauma in his practice with variability in clinical presentation. In this study includes the incidence, clinical presentation, surgical management, post-operative complications, correlation of USG and FNAC of salivary gland swellings with histopathology was done. To evaluate incidence according to age and gender distribution, accuracy of USG and FNAC in diagnosis and current surgical management of salivary gland swellings. This prospective observational case series of 25 patients studied over a period of 2 years presented with salivary gland swellings in our institution who are willing for Investigation and treatment. The case history, diagnosis with pre-operative USG, FNAC with post-operative histopathological correlation and surgical management and complications were assessed. Patients were aged between 4-65 years with presentational mean age of 37.2 years with male to female ratio of 3:2. Parotid gland is most common salivary gland involved of 21 cases. Most are of neoplastic origin with pleomorphic adenoma as commonest. 3 cases were misdiagnosed on USG in comparison with FNAC &amp; histopathology with diagnostic accuracy of USG as 92%, while 100% diagnostic accuracy of FNAC observed in comparing with histopathology reports. Superficial parotidectomy was the most common surgery performed of 19 cases. Comparing to USG, FNAC is best helpful in diagnosis but histopathology is the gold standard. Salivary gland excision was the best surgical approach towards pathology of salivary gland swellings.</p>