Abstract : The focus of this study was to assess sella turcica size and shape utilizing advanced image; and to find if there is any significant difference in these variables of sella turcica as concerns to the gender, age, and groups. Data included 41 CBCT images divided into two groups: a patient group with cleft lip or palate (20 patients: 7 females and 13 males, aged between 16 and 26 years) and control group (21 subjects: 9 females and 12 males, aged between 17and25 years). Linear measurements such as length, depth, and diameter of sella turcica were investigated and its shape was described in each group. Information was analyzed by using the SPSS version 21 to compare between groups and find any statistical significance. The means of all variables appeared bigger in cleft (length: 9.65; depth: 7.94; diameter: 11.61) than normal (length: 8.6; depth: 7.79; diameter: 11.48) groups. Furthermore, each age and length observed statically significant differences between two groups (T-test:3.280, p-value:.002; T-test: 3.056, p-value:0.002) respectively. The anatomical study of sella turcica including form and dimension in normally and its difference using CBCT could be valuable for the dentist to analyze differences associated with cleft conditions and realized the reason of some signs for good diagnosis and prognosis