Vol - 28, Issue - 06
About the Journal
[This article belongs to Volume - 28, Issue - 06]
International Medical Journal
Journal ID : IMJ-07-08-2021-853
Total View : 738

Abstract : <p>This study was conducted with an objective to compare the efficacy of Recombinant Human Epidermal Growth Factor (rHEF) in healing of diabetic ulcers with conventional dressings, also in terms of rate of healing and duration of hospital stay. A prospective study with a total of 50 Diabetic ulcer patients between 18 and 75 yrs of age were taken for the study and were divided into 2 groups of 25 each. Only ulcers of &lt;/= to Grade II of Wagner classification were included. Group E: Patients received dressing using Recombinant Epidermal Growth factor (All of them were from a single company). Group C: Patients received Conventional dressing using Povidone iodine, H2O2, EUSOL and Normal saline. Patients were observed for a total of 6weeks each or until the complete wound healing had occurred, whichever was earlier, and were evaluated after every week for wound size and rate of wound healing. Complete healing of ulcer was observed in 21(84%) patients of Group E, whereas only 17(68%) among Group C showed complete healing. Rate of decrease in the size of the ulcer was significantly higher among Group E than in Group C patients (P &lt;0.05). Also mean duration of hospital stay among patients in Group E was 14.2 days compared to 18.9 days in those patients in Group C. This difference was also statistically significant (p value&lt;0.001, significant) This study demonstrates the positive effect of topical rHEGF in significantly speeding up wound healing and its efficacy in healing of diabetic ulcers.</p>

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