Abstract : All patients admitted with clinical diagnosis of “Diabetic or Non-Healing ulcers or traumatic ulcers” under General Surgery care in SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE were taken as Subjects for this study with a sample size of 116 in each group based on previous study. After initial assessment of wound as per the PUSH criteria (Pressure Ulcer Scale of healing) initial wound debridement was done and in silver Nano group ulcer were treated with silver Nano colloid gel and in conventional group ulcer are treated with saline. Patients were then subjected to regular investigations and dressings. The wound was assessed as per PUSH scale for a period of 8 weeks. Wound score was noted at 2nd, 4th, 6th and 8th weeks of the study and the data collected were evaluated statistically with p value less than or equal to 0.05 as an indicator of statistical significance. After treatment, in silver nano group, wound score is 4.20 and in conventional group it is 6.88. There is statistically significant association between two groups with respect to wound score (P=0.01). The two groups are similar with respect to wound area at baseline,2 weeks and 4 weeks. They differ statistically with respect to wound area at 6 weeks and 8 weeks (P=0.01). Amount of exudate is similar in both the groups at baseline. They differ statistically at 2,4,6th and 8th week. Amount of exudate is less in the silver nano group compared to conventional group. The two groups are comparable with respect to type of tissue at base line and second week. They differ statistically at 4th, 6th and 8th weeks. There is early granulation followed by rapid epithelisation in silver nano group compared to conventional group. The percentage reduction in score as per PUSH scale is calculated. In silver nano group 74.40 reduction score and in conventional group it is 60.80 which is of statistical significance. Mean duration of hospital stay was significantly less in silver nano group compared to conventional group. In Present study to assess the role of silver nano colloid in treatment of diabetic ulcer we conclude that silver nano colloid particles are effective in treating patients with diabetic ulcers than that of conventional dressings in terms of wound size, exudate amount, and tissue type."