Abstract : Diabetes is a chronic non communicable disease that is currently the leading cause of morbidity and mortality in the world. Diabetes mellitus is expected to be the seventh leading cause of mortality by 2030, according to the world health organization (WHO). This Prospective Comparitive study was conducted to mainly compare the management of diabetic foot ulcers with Superoxidized solution and Povidone Iodine solution at Dr. D. Y. Patil hospital and research center, Pune during the period of September 2019 to August 2021. This prospective study was conducted among 60 patients with diabetic lower limb ulcers. The mean age in group A was 58.33 years where as in group B it was 55.43years. 82% of the patients were males and 18% were females. The mean random blood sugar level was 254.27mg/dl and 254.90mg/dl in group A and group B respectively. The mean HbA1c was 8.0% and 8.22% in group A and group B respectively. The most common organism isolated was staphylococcus aureus followed by pseudomonas. Mean healing time for wound was significantly lower in group A (37.11 days) than group B (52.76 days). The mean time for nil growth on culture for group A was 15.12 days and group B was 15.58 days. The current study shows that superoxidized solution had statistically significant advantages over povidone iodine in healing of diabetic ulcers. In present study, with moistening properties, cost effectiveness, rapid wound healing, non-irritability and reduced hospital stay of superoxidized solution has advantage over the traditional povidone iodine.