Abstract : Ligation of intersphincteric fistulous tract (LIFT) was introduced by the Thai surgeon [5]. The present study compared the efficacy of ligation of intersphincteric fistulous tract with that of open fistulectomy procedure in the management of fistula-in-ano in terms of postoperative pain and bleeding, wound healing, recurrence over a period of 6 months and fecal continence. Over a period of 18 months, fistula-in-ano patients attending a tertiary hospital were enrolled in the study. About 46 patients were assigned to Group A (LIFT) and Group B (Fistulectomy) each in a randomized manner. Patients underwent the procedure and were followed up in immediate post-operative period and for a period of six months. The average hospital stay of patients from Group A (2.5 days ± 1.09 SD) was lesser than that of patients in Group B (3.26 days ± 1.02 SD). The wound healing rates were better in those undergoing LIFT in Group A (1.09 ±0.35SD) than in Group B (1.30 ±0.63SD). [p value: 0.043]. Patients in Group A (LIFT group) reported no fecal incontinence, lesser post-operative bleeding and pain, and lesser recurrence. Overall, the present study demonstrated a better side effect profile with LIFT as compared to Fistulectomy; and better short term results. These results are promising and validate the global interest in LIFT. Further research is necessary to cement the role of LIFT in management of fistula-in-ano, particularly in terms of long-term outcomes.