Abstract : "An acute inflammatory process of the pancreas, with varied involvement of other regional tissues or remote organ systems". Acute Pancreatitis is a reversible inflammatory condition of the pancreas with minimal or no fibrosis of the tissue. Chronic pancreatitis has ongoing inflammation, irreversible structural changes, and persistent damage of exocrine as well as endocrine pancreatic function. Acute pancreatitis does not. Gallstones, alcohol, trauma, drugs, post ERCP and anatomic obstruction are all causes of acute pancreatitis [1]. Patients who suffer from acute pancreatitis are at a higher risk of developing further complications like sepsis, shock, respiratory failure, and kidney failure, all of which can lead to death or serious illness. A large number of peptides are synthesized in and by endocrine cells of the pancreas and gastro-Intestinal tract. Many of these peptides circulate as hormones, but they also function as paracrine modulators or neurotransmitters in the gut and in the central and Peripheral nervous systems [2]. Heparin with a low molecular weight (LMWH) has a stronger moresafer anti-thrombin action than unfractionated heparin. LMWH improves pancreatic microcirculation by reducing cytokine and inflammatory mediator release [3]. LMWH inhibits the start of an inflammatory storm, which improves the microcirculation system, and it has an anti-thrombus action, which reduces the development of microthrombosis in the pancreas. Acute pancreatitis can be successfully treated with LMWH [3].