Abstract : Quality of life is a broader term than Health-Related Quality of Life(HRQoL), as it involves the evaluation of components that extend beyond physical and mental health such as educational, spiritual, financial, social and environmental. In this study, we have focused on assessing the quality of life among parents of children with malignancy. A descriptive cross-sectional study was conducted among 110 parents whose child was diagnosed and undergoing treatment in tertiary medical care hospital. Purposive sampling was used to select the sample size. Data was collected using the WHOQOL-BREF questionnaire and data analysis was done using SPSS software. The mean scores obtained by the parents in different domains along with perceived overall QoL and perceived health status. On assessing the quality of life using the WHOQOL-BREF questionnaire, the study participants obtained the highest mean score of 58.51±15.51 in the Physical domain. Certain factors like education, working status, type of family, Socioeconomic status, treatment covered under insurance, support from Government /NGOs, support from family/ friends are modifiable and help in improving the quality of life.