Abstract : To study the incidence and risk factors affecting surgical site infections, To determine the incidence and risk factors of surgical site infections and to assess the most common organism encountered in surgical site infection. The material for the present study was obtained from patient’s undergone surgery in Department of General Surgery, Government general hospital, Nizamabad from 01-04- 2021 to 31-05-2022. Surgical site were considered to be infected according to the definition by NNIS. A study of 100 operated cases was carried out of which 18 were diagnosed to be having surgical site infection as per the CDC criteria. Incidence of surgical site infection in this study is 18%. Majority of infected cases in the study belong to age group of 51-60 years with an incidence of 37.5%. Elective had an incidence of 12% and emergency cases had more incidences of 24%. Most of the cases had SSI detected on 3rd post-operative day.