Vol - 29, Issue - 01
About the Journal
[This article belongs to Volume - 29, Issue - 01]
International Medical Journal
Journal ID : IMJ-11-01-2022-1183
Total View : 397

Abstract : Peptic ulcer disease is a global problem with a lifetime risk varying from 5-10%. Peptic ulcers are defined as erosions occurring in duodenal or gastric mucosa which extends into the muscularis mucosa. Approximately 80-90% of peptic ulcers are associated with H.Pylori infection and the identification of H.Pylori as a prominent risk factor for PUD has revolutionized our understanding of the etiopathogenesis of peptic ulcer disease. This study was taken up to evaluate the prevalence of H. pylori infection in patients with acute perforated peptic ulcers in patients admitted in a tertiary care centre. This study also aims to highlight other overlapping risk factors associated with peptic ulcer perforation. The Mean age of 30 study sample was 48.07 years (standard deviation – 11.65 years. History of NSAIDs intake (11), spicy food (9) were also present in some subjects. Some subjects were having more thaan one risk factor among study samples. H pylori was present in 5 out of 12 gastric perforation subjects and 8 out of 18 duodenal perforation subjects on histopathology. Among 30 cases 13 (43.3%) were confirmed to be positive for H.pylori infection and among those 13 cases only 5 ( Sensitivity : 38.46% ) cases had positive for urease test and 3 ( Sensitivity : 23.07% ) showed growth on culture media. This study shows that there is a positive correlation between H.pylori infection and acute perforated peptic ulcer. The incidence of H.pyori however has reduced over the past decade which could be due to over the counter use of H.pyori eradication therapy or we need to evolve more sensitive modalities for detecting H.pylori. in low bacterial count cases.

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