Abstract : Renal cell carcinoma comprehends a heterogeneous group of tumors which account for 2% of all cancers diagnosed. About 80-85% of all renal cell cancers affect males compared with females in the ratio 3:2. The overall incidence increases with life style. In rare instances, RCC affects children and young adults. The present study investigated the serum Vitamin D, calcium, Phosphorous and Magnesium levels in renal cell carcinoma patients. This is a Descriptive Study which includes five groups; Sample size of this study was 60. The study was conducted during the period from January 2017 to August 2018 in the Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamil Nadu. In the present study it was observed that the Vitamin D, calcium, Phosphorous and magnesium levels in serum were significantly decreased (p<0.001) in renal cell carcinoma patients as the disease progresses. Vitamin D deficiency is profound in RCC, with deficiency status increasing as the disease progresses from stage I to stage IV. In the present study we conclude that Vitamin D is a prognostic marker for Renal Cell Carcinoma.