Vol - 29, Issue - 01
About the Journal
[This article belongs to Volume - 29, Issue - 01]
International Medical Journal
Journal ID : IMJ-07-01-2022-1173
Total View : 354

Abstract : To determine the frequency of thyroid function abnormalities in patients with septicemia. Faisal Hospital Karachi from July to December 2021. This crossectional study was conducted in the medical wards and Intensive care unit of Faisal Hospital Karachi. Total 100 consecutive patients of either gender age 14 years and above admitted with the diagnosis of septicemia were included and venous blood sample was collected for determination of Free T4 (FT4), Free T3 (FT3), and Thyroid stimulating Hormone (TSH) levels within 24 hours of admission. Those who have known thyroid illness, having history of thyroidectomy, pregnancy, and puerperium and on medications causing alteration of thyroid function were excluded. Statistical Package for Social Sciences (SPSS) version 25 was used for the data analysis. Mean age of the participants was 48.9+ 20.3 years and 48% were male and 52% were females. Around 86% had FT3 lower than 1.4pg/ml, 56% had FT4 lower than 0.8ng/dl and 64% had normal TSH. Around 50% of the participants were expired in this study. In expired patients 44(51.2%) had low freeT3, 36(64.3%) had low T4 and 8 (25%) had low TSH. This study demonstrate that TSH levels are within normal range in most patients while FT3 and FT4 are markedly low, and among those who died more than 50% had low T3 and T4. Thyroid dysfunctions are common among female septic patients as compared to males. There is an association in between abnormal thyroid functions and the mortality in septic patients so these patients should have to be treated appropriately.

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