Vol - 28, Issue - 09
About the Journal
[This article belongs to Volume - 28, Issue - 09]
International Medical Journal
Journal ID : IMJ-13-09-2021-929
Total View : 348

Abstract : The bidirectional gut brain axis has gained a lot of importance recently. The gut brain axis is made up of various systems, which includes the endocrine, immune, autonomic, and enteric nervous system. The human microbiota has been linked to various health and disease components. Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis. Few mediators have been identified which has a role in establishing communication between the gut and brain. Alteration in the bidirectional gut-brain microbiota interaction has been implicated as a possible mechanism in the pathophysiology of several brain disorders including depression. Depression can be due to various factors and to know the various mediators this review is done.

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