Abstract : Autoimmune thyroid illnesses such as Grave's, Hashimoto's, atrophic autoimmune thyroiditis, postpartum thyroiditis, and others can be induced by thyroid antibodies. In some circumstances, cytological diagnosis can be challenging. Cytology and serological testing aid in accurate diagnosis in these circumstances. Since anti-TPO antibody levels are important in identifying autoimmune thyroiditis, this study was conducted to examine their relationship to thyroid hormone levels and their significance. When looking at the risk ratio of PTC in HT patients, most FNAC studies used multivariate statistical analysis to explore the relationship between elevated TSH levels and cancer, but this was not always linked to HT. Contrarily, a number of studies have shown an association between ATA and PTC that is especially strong when using TgAb. An independent risk for thyroid cancer was observed to be associated with both TPOAb and TgAb, indicating the involvement of elevated thyroid stimulating hormone (TSH) levels, and a substantial connection between PTC and ATA and diffuse LTI at histology was found.