Abstract : This study aimed to evaluate the homogeneity of mixing calcium carbonate (CaCO3) with nano-hydroxyapatite (HA) by electrophoretic deposition (EPD) and assess the effect of coating commercially pure titanium (CP Ti) implant with this mixture on bone-implant interface strength after implantation in the femurs of rabbit for two and six weeks through torque removal test. In this study, CaCO3 and nano HA were mixed in the same proportion, the EPD method was used for the deposition of this mixture on the CP Ti implant screws, which were implanted in the femurs of eight rabbits. Osseointegration between coated screw implants and bones were assessed using the torque removal test two and six weeks after implantation and compared with osseointegration between uncoated screw implants and bones. The CaCO3 and nano-HA mixture were deposited without cracks on titanium by EPD. The torque removal values were higher in coated screw implants than in those of uncoated screws at both periods of implantation and have a mean value of 4.8 N.cm for two weeks and 17.2 N.cm for six weeks. The values in uncoated screws had mean values of 2.6 and 10.7 N.cm, respectively. The mixture of CaCO3 and nano-HA was deposited homogenously and properly on the CP Ti by EPD. The mixture-coated screw implants showed higher torque removal values than the uncoated screw implants at two- and six-week implantation periods and thus had a higher degree of bone-to-implant integration