Abstract : The present study aimed to assess self-care management of patients with heart failure in king Khaled hospital in Najran city southern kingdom of Saudi Arabia. A descriptive cross-sectional study design was conducted on 52 patients with heart failure admitted to the king Khaled hospital - cardiac department .data were collected to assess self-care management which regarding to compliance of treatment medication, sodium, restriction of fluid, take weights daily, practice regular exercises, and keeping appointment. The data were collected from all patients and the analyzed using SPSS version 23 software. The result of present study revealed that of 52 patients’ compliance ranged between 9.6% and 86.5 % of the patients. the high rate of compliance was found in Keeping follow-up appointments 45(86.5) % and take your medications exactly   as directed 43 (65.3%). The highest rates of non-compliance are found in fluid restriction 47(90.3%) , and exercise 40(76.9%) ,and  follow a low sodium diet 30 (57.7%). The present study shows that knowledge deficit is seem the most important reason of poor self-care management, lack of knowledge to avoid drinking excess fluids 46 (88.5%), lack of knowledge to comply with the dietary High in potassium, 43(82.6%) and lack of knowledge   to weight myself daily 37(71.1. The result of the present study concluded that low knowledge of the patients about their illness which reflect on poor self-care of HF patient