Abstract : Tobacco smoking is a global epidemic and health threat that continues to increase. Nursing students primarily develop their professional roles in smoking cessation during their academic nursing education. The purpose of the study is to examine the effect of smoking (cigarette, Hookah) during student life in his/her university. Using convenience sampling, a descriptive cross-section research design was used. Participants were nursing undergraduate students from AAUP, Palestine. Four hundred and thirteen participants participated in the study. More than half of the participants were smokers 233 (56.4%). Of those who had smoked, about 223 (54.0%) were tobacco smokers while 161 (39.0%) Hookah smoking. Around 52.8% of participants complain of headaches, 44.2% of participants complain of nervousness, and 3% of participants complain of hand tremors. A moderate relationship between smoking and gender while a small relationship with age, but there was no relationship with GPA. According to smoking Hookah, no relationship with gender or age, while a moderate relationship with GPA. The high percentage of smoking in 21-24 years. A moderate relationship between smoking and gender while a small relationship with age, but there was no relationship with GPA. According to smoking Hookah, no relationship with gender or age, while a moderate relationship with GPA. The study showed that the participants feel headache, nervousness, and a little effect hand tremor