Abstract : <p>Obesity has reached epidemic proportion in India with morbid obesity affecting 5% of country&rsquo;s population. As the rate of Obesity climbs, obesity related diseases and conditions follow with similar rates. Adipose tissue is an active endocrine organ that releases several cytokines such as IL-1, IL-6 TNF-&alpha; and adipokines such as leptin, adiponectin, hepcidin, resistin. This study is to analyze if there is any association of Obesity with Hepcidin in men. This case-control study was conducted at a tertiary care centre in Tamil Nadu between Dec 2013 and Nov 2014, including 80 subjects of South Indian population, of male sex. The biochemical parameters which were measured included the levels of hepcidin, ferritin, iron and TIBC. The results obtained were statistically analyzed using SPSS software version 15.0. Mean and Standard deviation were found for all parameters. Independent sample t-test and ANOVA were performed to check for the statistical significance for differences in mean between the groups. The mean hepcidin values for the control group was 756 &plusmn; 411 and the study group was 1122 &plusmn; 930 and when compared it was found to be statistically significant with a p-value of 0.032. Hepcidin is predominantly produced by hepatocytes and also in adipose tissue, recognized as the key regulator of systemic iron homeostasis. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.</p>