Home
About Us
Information & Guidelines
Article Processing Charges
Open Access Policy
Terms and Conditions
Privacy Policy
User Feedback
Information For Authors
Information Editorial Board
Contact Us
FAQ
Paper Submission Guideline
Register
Login
Submit Now
Vol - 25, Issue - 5
Full-Text PDF
About the Journal
Download
[This article belongs to Volume - 25, Issue - 5]
International Medical Journal
Journal ID
:
IMJ-15-04-2020-421
Total View
:
247
Title
:
Associations of Vitamin D levels and VDR BsmI (rs1544410) and FokI (rs2228570) Gene polymorphisms with Bone Mineral Density in Iraqi patients with Beta Thalassemia Major.
Abstract
: Vitamin D is considered to be of high importance in the bone’s mineralization. The Vitamin D receptors genetic polymorphism might be associated with the status of vitamin D besides the bone mineral density that have been characteristic features related to the Beta thalassemia major (β-TM) patients. The presented work has been conducted on 100 patients with β-TM in addition to 100 healthy age and sex matched controls for the purpose of evaluating the impact related to VDR polymorphisms on the levels of vitamin D in addition to the bone mass density (BMD). Furthermore, the serum biochemical markers like alkaline phosphates, inorganic phosphorus, ionized calcium as well as vitamin D have been evaluated. The VDR genetic polymorphisms (FokI and Bsml) have been genotyped through the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR). Also, the BMD has been evaluated through X-ray densitometry (DEXA) related to lumbar spine and femoral neck. The results that are related to β-TM patients showed considerable deficiency of vitamin D, also the BMD Z score has been considerably low in the β-TM patients when compared to the non-thalassemic subject (p < 0.001). Osteopenia as well as osteoporosis related to lumbar spines and femoral neck have been indicated in the β-TM patients. Furthermore, the BsmI AG in addition to the FokI CT genotypic polymorphisms have been considerably related to low vitamin D as well as BMD Z score. The low BMD has been widespread in the patients experiencing β-TM. Also, the BsmI AG as well as the FokI CT genotypic polymorphisms related to the VDR might be specified as risk factors for the include regarding osteoporosis in such β-TM patients
Download Info
×
Paper Access Key
Access Key
Submit
No Access Key (
Request for Download
)
Name
Email
Country
Send Request
Our Certificates
Guidelines
Information For Authors
Information Editorial Board
FAQ
Further Information
Article Processing Charges
Open Access Policy
Terms and Conditions
Privacy Policy
User Feedback