Abstract : This study aimed to investigate intubation success using the new C-MAC video laryngoscope (VL) in comparison with the traditional flexible fiber-optic laryngoscopy (FFL) in patients with head and neck cancer with an anticipated difficult airway. This prospective study included 72 patients scheduled for major surgery due to cancers involving the head and neck. Routine preoperative assessment was done in addition to the LEMON scoring system to predict difficult intubation. The participants were randomized into two groups; C-MAC Group intubated with a C-Mac VL and Fiberoptic Group intubated with FFL. Hemodynamic variables, intubation time, number of intubation attempts, and attacks of hypoxia during intubation. LEMON score of all patients ranged from 7 to 9, with no significant difference between the two groups (p = 0.463). The intubation success rate was 100% in the Fiberoptic Group from the first attempt in all patients compared to 94.4% in the C-MAC group (p= 0.493). Four patients out of the 34 successful cases in the C-MAC group needed a second attempt of intubation. Intubation time was 32.4±4.9 seconds in the Fiberoptic Group compared to 14.9±3.9 seconds in the C-MAC group (p < 0.001). The hemodynamic characteristics were within the clinically accepted range in the two groups 1 and 5 minutes after intubation. C-MAC video laryngoscopy can be a useful alternative to fiberoptic bronchoscope for the management of difficult intubation in patients with head and neck cancers. It has similar efficacy and safety and shorter intubation time