Abstract : Increasing the prevalence of smoking in developing countries and aging populations in highincome countries, is expected to increase the prevalence of Chronic Obstructive Pulmonary Disease (COPD) in the next 40 years. In this research, we will find out the role of A Disintegrin And Metalloprotease (ADAM) 33 gene expression based on the theory of inflammation involving proinflammatory cytokines (IL-6 and IL8) and anti-inflammatory (IL-10). This study is a cross sectional study comparing COPD and non-COPD patients with a comparative study approach. In this study there were 2 groups: a stable group of COPD patients (33 male COPD patients; 4 female COPD patients) and a non-COPD patient group (25 male patients 4 female patients). Univariate analysis to assess the characteristics of research respondents. Whereas bivariate analysis was carried out to compare these parameters between the two groups. Parametric tests were carried out on the normal distribution with Independent sample t test and non-parametric test (Spearmann Correlation) for abnormal sample distribution. This study shows that differences in soluble IL-6 and IL-8 levels are higher in COPD patients than in non-COPD patients, whereas soluble IL-10 levels are lower in COPD patients than in non-COPD patients who are statistically significant. There is a significant linear correlation, soluble cytokine levels of IL-6, IL-8, and IL-10 with levels of soluble ADAM33 in COPD patients through the Spearmann Correlation test (p<0.001). The levels of soluble ADAM33 have a positive relationship with IL-6 and IL-8 and a negative relationship with IL-10 in the inflammatory reaction of COPD patients