Abstract : Nephrectomy is done to treat a number of kidney diseases including kidney neoplasms. Pathology department routinely receives nephrectomies and kidney biopsies. This study was undertaken to analyze the clinicopathological & histomorphological spectrum of neoplastic lesions of kidney. This study was carried in Department of Pathology, Dr. D. Y. Patil Medical College and Hospital, Pimpri, Pune. All kidney biopsies and specimens were collected and analyzed. This was a prospective study conducted from July 2018 to July 2020 which had a total of 35 kidney lesions were submitted. Among the adults, there was a wide age group range from 4th to 6th decade of life. Childhood tumors ranged from 1month to 2 years of age. In this study there was male preponderance. The most usual presenting symptom is flank pain and mass in the abdomen. Malignant tumors have outnumbered the benign ones. Renal cell carcinoma is most common type of kidney malignancy. Wilms s tumor is the most common childhood tumors. Various histological subtypes and grading will give better information regarding treatment, diagnoses and prognosis of the disease. Majority of the malignancies in kidney are diagnosed at advanced stage.