Abstract : Breast cancer is most common cancer in female, both worldwide and in India. Better health awareness, availability of screening programs and treatment modalities can cause a favourable and positive clinical picture in India. Aim of present study is to evaluate Clinical features, Investigations, various treatment protocols and outcome for Locally Advanced Breast Cancer. This is a prospective descriptive observational study of 100 patients with locally advanced breast carcinoma admitted in Surgery OPD at Dr. D. Y. Patil Medical College, Pimpri, Pune during the period of August 2018 to September 2020 after obtaining due consent from the participants. Data collection included a detailed history and a thorough clinical examination which is entered in the proforma, tabulated and analysed using software package of statistical analysis (SPSS 22.0). Out of 100 cases of locally advanced breast carcinoma (LABC), majority of the cases were in between 41 - 60 years (74%) and 68% were post-menopausal. Lower economic status had direct effect on cancer incidence (62%). Breast lump is the most common presenting symptom. Majority (73%) had a tumour size more than 5 cm and axillary lymph node metastases. Most common histologic type is ductal type and most of them responded to neoadjuvant chemotherapy followed by surgery +/- radiotherapy +/- hormonal therapy +/- chemotherapy. It is needed that awareness regarding breast carcinoma in general should be imparted to at risk population with a special emphasis on those from lower socio-economic class and those having lower literacy levels to improve the outcome.