Abstract : Most studies on the role of oncogenic viruses in the development of prostate carcinoma focus on one particular type of virus without analysing the different interactions that may exist between two or more types of virus. The objective of this study was to examine co-infection with BKPyV, MCPyV, PyV6 and PyV7 viruses in men with PCa (Pca) and their correlations with characteristics clinicopathologic patients. In this study, a total of 80 samples were summer analyzed ; 50 blood samples from of men patients with PCa have summer used to detect BKPyV, MCPyV, PyV6 and PyV7 in blood samples using PCR techniques and 30 control samples, and clinical significance has been analyzed statistically. Of the 50 samples tested, 36% were infected with BKPyV, 24% with PyV6 and 28% with PyV7. A correlation significant to summer observed between the Pathological Gleason score and BMI in co- infected patients. In fact, she can to have an important role in initiation and/ or growth of oncogenic transformation. Our results show that BKPyV PyV6 and PyV7 are cofactors potential for PCa in cases positive for BKPyV, which may lead to the development of new therapies and vaccines preventive.