Abstract : The aim of this study is to assess the cognitive status level for patients with End-Stage Renal Disease (ESRD) undergoing hemodialysis and its relationship with sociodemographic and clinical characteristics. A descriptive, correlation, cross-sectional design was used in this study by a convenience sample of 188 ESRD patients chosen from dialysis units from different health system sectors in Jordan. The Mini-Mental State Examination scale (MMSE) was used to assess the cognitive status level. The mean and SD of MMSE scores were {23.4± 4.23}, about 55.7% of the participants had cognitive impairment in three different levels; mild, moderate and severe, and a negative relationship between cognitive status level and age, gender and smoking. The results of this study could help to shed light on cognitive impairment related hemodialysis and demographic and/ or clinical characteristics. This could lead to a better understanding of cognitive impairments among medical teams who may initiate advanced interventions that improve treatment and quality of life for hemodialysis patients in Jordan