Abstract : The aim of this study was to compare the clinico-microbiological efficacy of 1% Chlorhexidine Gel(CHX)and 10% Propolis Gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis patients. 30 sites in 10 patients with chronic periodontitis and similar probing depths were selected for the study that were equally divided into 3 groups: SRP alone (Group A), SRP in conjunction with the placement of 1 % chlorhexidine gel (Group B) and SRP in conjunction with the placement of 10% propolis gel (Group C). Clinical parameters were recorded at baseline, 4 weeks and 12 weeks that included Gingival Index, Plaque Index, Probing Depth, Relative Attachment Level And Relative Gingival Margin Level. Microbiological samples were taken at baseline and 12 weeks. The numbers of total bacteria were quantified. At 12 weeks post-treatment, all groups improved from baseline levels. However, statistical analysis revealed greater improvement in all clinical parameters in Group B compared to Group A and Group C. There was also a significant reduction in the total number of bacteria over this period, with a greater reduction observed in the Group B compared to Group A and Group C. Although both treatments seemed to benefit the patients, the adjunctive use of 1% chlorhexidine gel following scaling and root planning enhanced the clinical and microbiological results compared to the adjunctive use of 10% propolis gel and SRP alone.