Abstract : Anaesthesia techniques generally involved in lower limb orthopedics surgeries are central neuraxial blockade techniques. Central neuraxial blockade usually achieved with either spinal anaesthesia, epidural anaesthesia or combined spinal anaesthesia. Proximal femur nailing is most commonly done under spinal anaesthesia. Spinal anaesthesia is most frequently associated with hypotension. The current study compares the use of Phenylephrine and Mephentermine in managing hypotension after subarachnoid blockade, and its efficacy in maintaining patient’s blood pressure to normal. A randomized, prospective study over 100 patients mostly adults both male and female who have given spinal anaesthesia for proximal femur nailing are selected. They are grouped into first 50 of group X who have given Phenyephrine and second 50 of group Y who have given Mephentermine. During study, number of allequate doses of drug and other side effects of individual drug were documented. Results were documented with the help of student’s paired t test and Chi square test. 33 hypotensive events occurred in Mephentermine group and 44 hypotensive events occurred in Phenylephrine group. Mean heart rate in Phenylephrine group was lower as compared to Mephentermine group. Mephentermine is more effective as compared to Phenylephrine in treating hypotension after spinal anaesthesia also have less recurrence rate.