Abstract : This study is conducted to compare harmonic scalpel versus electrocautery in laproscopic cholecystectomy with respect to operative time/complications, post-operative pain and time to resume activity in patients operated in our institute. Prospective observational study was conducted in our institute from September 2019 to August 2021 following approval from Ethical committee of hospital. Prior to surgery, all patients were kept nil by mouth overnight and given a prophylactic antibiotic dose. All of the procedures were conducted by the same surgical team, under general anesthesia, and intra-operative and post-operative data were all documented. Mean age of 100 study sample was 49.50 years (SD – 5.651 years), with highest 63 years and lowest 38 years. Abdominal pain most common complaint present in 60 subjects followed by nausea (20) & vomiting (15). Intraoperative complications more in laproscopic cholecystectomy where gall bladder removed by electrocautery (32) than with harmonic scalpel (5). Bile leak, gall bladder perforation and stone spillage are common complications with electrocautery. Mean surgery duration, frequency of lens cleaning, post-operative pain score for laparoscopic cholecystectomy with harmonic scalpel was lower than with electrocautery and the difference was statistically significant (p=0.000). Mean duration to resume daily activity (days) for laparoscopic cholecystectomy with harmonic scalpel was lower than with electrocautery and the difference was statistically significant (p=0.000). As per our study, we inferred that harmonic scalpel use is associated with less intra-operative time/complication and post-operative pain, as compared with the use of electrocautery.